Progress in Oncogene Research

Adaptor proteins in signal transduction. 6. Transcription factors. This new book covers topics from within this field of research.

Progress in Oncogene Research

An oncogene is a gene that can cause a cell to develop into a tumour cell, possibly resulting in cancer. A protooncogene is a gene that is involved in signal transduction and execution of mitogenic signals, usually through its protein product. Upon activation, it (or its product) becomes a tumour inducing agent, an oncogene. The protooncogene can become an oncogene by a relatively small modification of its original function. Growth factors are usually secreted by a few special cells to induce cell proliferation in other cells. If a cell that usually does not produce growth factors suddenly starts to do so (because it developed an oncogene), it will thereby induce its own uncontrolled proliferation (autocrine loop), as well as the proliferation of neighbouring cells. There are six known classes of protein kinases and related proteins that can become an oncogene: 1. Receptor tyrosine kinases that become constitutively (permanently) active like the epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR). 2. Cytoplasmic tyrosine kinases like the Src-family, Syk-ZAP-70 family and BTK family of tyrosine kinases. 3. Regulatory GTPases, for example, the Ras protein. 4. Cytoplasmic Serine/Threonine kinases and their regulatory subunits, for example, the Raf kinase, and cyclin-dependent kinases (through overexpression). 5. Adaptor proteins in signal transduction. 6. Transcription factors. This new book covers topics from within this field of research.

More Books:

Progress in Oncogene Research
Language: en
Pages: 266
Authors: Laura S. Peale
Categories: Medical
Type: BOOK - Published: 2006 - Publisher: Nova Science Pub Incorporated

An oncogene is a gene that can cause a cell to develop into a tumour cell, possibly resulting in cancer. A protooncogene is a gene that is involved in signal transduction and execution of mitogenic signals, usually through its protein product. Upon activation, it (or its product) becomes a tumour
Recent Advances in Cancer Research and Therapy
Language: en
Pages: 700
Authors: Xin-Yuan Liu, Sidney Pestka, Yu-Fang Shi
Categories: Medical
Type: BOOK - Published: 2012-05-18 - Publisher: Elsevier

Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews
Progress in Nucleic Acid Research and Molecular Biology
Language: en
Pages: 309
Authors: Xin-Yuan Liu, Sidney Pestka, Yu-Fang Shi
Categories: Medical
Type: BOOK - Published: 1988-11-01 - Publisher: Academic Press

Progress in Nucleic Acid Research and Molecular Biology
Progress Report
Language: en
Pages:
Authors: U.S.-Japan Cooperative Cancer Research Program
Categories: Medical
Type: BOOK - Published: 1988 - Publisher:

Books about Progress Report
Progress in Virus Research
Language: en
Pages: 336
Authors: Sabine Thebault
Categories: Medical
Type: BOOK - Published: 2006 - Publisher: Nova Publishers

The first part of the book deals with several aspects of different viruses : viral structure, function, replication and interplay between the virus and the host. Six viruses are used as examples, four RNA viruses (HTLV-I, HIV-1, MMTV and coxsackievirus B4) and two DNA viruses (EBV and KSHV). The second