The Selectivity of Drugs

1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode ...

The Selectivity of Drugs

1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode of action. out causing any change in others, even when the Drug therapy has two, fundamentally two kinds of cells are close neighbours. In living opposed divisions. The first of these strives to organisms, there are many substances, often improve the action of one of the cell's natural quite small molecules, which have been chosen agents by modifying the molecule in order to for their specificity. This choice has been made localize or intensify its action. For instance, under the strong pressure of natural selection, the solubility can be decreased to make it form unhurried by any consideration of time. Such a deposit, or a change is made so that it becomes chemical compounds operate the metabolism a poorer fit on the naturally-occurring destruc of the cells and tissues, and ensure their health, tive enzyme. Both of these devices have proved survival, and reproduction. Important among useful in therapy, e. g. with steroid hormones. the smaller of these selective molecules are Such drugs, which seek to improve on Nature vitamins, coenzymes, hormones, neurotrans by performing more desirably, are called mitters, inorganic ions, nutritional fragments, agonists.

More Books:

The Selectivity of Drugs
Language: en
Pages: 64
Authors: Adrien Albert
Categories: Science
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode of action. out causing any change in others, even when the
Receptor Data for Biological Experiments
Language: en
Pages: 289
Authors: Henri N. Doods
Categories: Science
Type: BOOK - Published: 1991 - Publisher: Routledge

Provides comprehensive coverage of the most relevant knowledge on classification, localization and biological effects of receptor systems and/or enzymes.
Drug Selectivity
Language: en
Pages: 536
Authors: Norbert Handler, Helmut Buschmann, Raimund Mannhold, Jörg Holenz
Categories: Medical
Type: BOOK - Published: 2018-02-05 - Publisher: John Wiley & Sons

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects.
Glutamate and GABA Receptors and Transporters
Language: en
Pages: 448
Authors: Jan Egebjerg, Arne Schousboe, Povl Krogsgaard-Larsen
Categories: Science
Type: BOOK - Published: 2001-10-04 - Publisher: CRC Press

The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover,
Functional Selectivity of G Protein-Coupled Receptor Ligands
Language: en
Pages: 292
Authors: Kim Neve
Categories: Medical
Type: BOOK - Published: 2009-02-27 - Publisher: Springer Science & Business Media

Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile.